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While this possible bias most likely did not affect effect sizes and their directions in the models due to the size of the studied cohort, it may have altered the width of the confidence intervals and thus the statistical significance of some findings

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The difficulty in manufacturing meant that cigarettes with filters were considered as more luxury items until 1935 when British company Molins introduced the first filter cigarette combining machine

That said, there are steps you can take to help stay nicotine-free for life